Interindividual variability and tissue-specificity in the expression of cytochrome P450 3A mRNA.

  title={Interindividual variability and tissue-specificity in the expression of cytochrome P450 3A mRNA.},
  author={Ina Koch and R. Weil and R. Wolbold and J. Brockm{\"o}ller and E. Hustert and O. Burk and A. N{\"u}ssler and P. Neuhaus and M. Eichelbaum and U. Zanger and L. Wojnowski},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  volume={30 10},
  • Ina Koch, R. Weil, +8 authors L. Wojnowski
  • Published 2002
  • Medicine, Biology
  • Drug metabolism and disposition: the biological fate of chemicals
  • The elucidation of the individual contributions of the four CYP3A genes to the overall CYP3A activity has been hampered by similarities in their sequence and function. We investigated the expression of CYP3A mRNA species in the liver and in various other tissues using gene-specific TaqMan probes. CYP3A4 transcripts were the most abundant CYP3A mRNA in each of the 63 white European livers tested and accounted on average for 95% of the combined CYP3A mRNA pool. CYP3A5 and CYP3A7 each contributed… CONTINUE READING

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