Interindividual differences of human flavin-containing monooxygenase 3: genetic polymorphisms and functional variation.

@article{Cashman2002InterindividualDO,
  title={Interindividual differences of human flavin-containing monooxygenase 3: genetic polymorphisms and functional variation.},
  author={John Richard Cashman and Jun Yu Zhang},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2002},
  volume={30 10},
  pages={1043-52}
}
The human flavin-containing monooxygenase (form 3) (FMO3) participates in the oxygenation of nucleophilic heteroatom-containing drugs, xenobiotics, and endogenous materials. Currently, six forms of the FMO gene are known, but it is FMO3 that is the major form in adult human liver that is likely responsible for the majority of FMO-mediated metabolism. The substrate structural feature requirements for human FMO3 is beginning to become known to a greater extent and a few chemicals extensively… CONTINUE READING

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