Interindividual Variability of the Clinical Pharmacokinetics of Methadone

@article{Eap2002InterindividualVO,
  title={Interindividual Variability of the Clinical Pharmacokinetics of Methadone},
  author={C. Eap and T. Buclin and P. Baumann},
  journal={Clinical Pharmacokinetics},
  year={2002},
  volume={41},
  pages={1153-1193}
}
Methadone is widely used for the treatment of opioid dependence. Although in most countries the drug is administered as a racemic mixture of (R)- and (S)-methadone, (R)-methadone accounts for most, if not all, of the opioid effects. Methadone can be detected in the blood 15–45 minutes after oral administration, with peak plasma concentration at 2.5–4 hours. Methadone has a mean bioavailability of around 75% (range 36–100%). Methadone is highly bound to plasma proteins, in particular to α1-acid… Expand
498 Citations
Interindividual Variability of Methadone Response
  • 63
Pharmacokinetics of Methadone
  • 154
Determination of the unbound fraction of R- and S-methadone in human brain
  • 5
Relationship between plasma concentrations of the l-enantiomer of methadone and response to methadone maintenance treatment.
  • 8
  • Highly Influenced
Effects of Hemodialysis on Methadone Pharmacokinetics and QTc.
  • 6
Reduced Methadone Clearance During Aromatase Inhibition
  • 6
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 250 REFERENCES
Plasma concentrations of the enantiomers of methadone and therapeutic response in methadone maintenance treatment.
  • 109
Pharmacokinetics of methadone and its primary metabolite in 20 opiate addicts
  • 74
  • Highly Influential
Steady-state pharmacokinetics of methadone in opioid addicts
  • 50
  • Highly Influential
Pharmacokinetics and pharmacodynamics of methadone in patients with chronic pain
  • 238
  • Highly Influential
Clinical Pharmacokinetics of Methadone
  • 95
Disposition of methadone in man after a single oral dose
  • 139
  • Highly Influential
Single dose pharmacokinetics and bioavailability of methadone in man studied with a stable isotope method
  • 62
  • Highly Influential
Methadone: a review of its pharmacokinetic/pharmacodynamic properties.
  • 139
  • Highly Influential
High-Dose Morphine and Methadone in Cancer Patients
  • J. Säwe
  • Medicine
  • Clinical pharmacokinetics
  • 1986
  • 198
Pharmacokinetics of methadone in methadone maintenance treatment: Characterization of therapeutic failures
  • 29
...
1
2
3
4
5
...