Interim analysis of a prospective randomized non-inferiority trial of cisplatin and fluorouracil induction chemotherapy with or without docetaxel in nasopharyngeal carcinoma.

@article{Jin2016InterimAO,
  title={Interim analysis of a prospective randomized non-inferiority trial of cisplatin and fluorouracil induction chemotherapy with or without docetaxel in nasopharyngeal carcinoma.},
  author={T Jin and Wei-Feng Qin and Feng Jiang and Qi-Feng Jin and Qichun Wei and Xiu-wen Tang and Yong-Shi Jia and Xiao-nan Sun and Wen-feng Li and Xing-Lai Feng and Xiao-zhong Chen},
  journal={Oncotarget},
  year={2016}
}
In this study, we aim to compare the progression-free survival (PFS) rates and side effects of induction chemotherapy based on docetaxel, cisplatin and fluorouracil (TPF) versus cisplatin and fluorouracil (PF) in patients with locoregionally-advanced nasopharyngeal carcinoma who received subsequent chemoradiotherapy. We randomly assigned 278 patients with stage III or IV NPC (without distant metastases) to receive either TPF or PF induction chemotherapy, followed by cisplatin-based… CONTINUE READING

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