Interictal spikes increase cerebral glucose metabolism and blood flow: a PET study.

@article{Bittar1999InterictalSI,
  title={Interictal spikes increase cerebral glucose metabolism and blood flow: a PET study.},
  author={Richard Garth Bittar and Frederick Andermann and Andre Olivier and François Dubeau and Serge O. Dumoulin and G. Bruce Pike and David C. Reutens},
  journal={Epilepsia},
  year={1999},
  volume={40 2},
  pages={170-8}
}
PURPOSE In patients with reflex epilepsy, it is sometimes possible to evoke interictal spikes predictably, thus providing an uncommon but important experimental paradigm for examining the physiological changes produced by epileptiform discharges. METHODS To examine the changes in regional cerebral blood flow (rCBF) and glucose consumption (rCMRglc) produced by interictal spikes, we performed positron emission tomography (PET) scans with the blood-flow tracer [15O]H20 and with [18F… CONTINUE READING