Intergenic suppression of the black mutation of Drosophila melanogaster

  title={Intergenic suppression of the black mutation of Drosophila melanogaster},
  author={Allen F. Sherald},
  journal={Molecular and General Genetics MGG},
  • A. F. Sherald
  • Published 2004
  • Biology
  • Molecular and General Genetics MGG
SummaryFive X-linked, recessive alleles were isolated which suppress both the pupal and adult coloration phenotypes of the black mutation. Electron micrographs of shed puparia revealed that the aberrant sclerotization of the black cuticle is also suppressed. Amino acid analysis indicated that suppression is associated with an increased concentration of β-alanine, an amino acid known to be deficient in black. The suppressor locus mapped at the tip of the X, to the right of scute, and intragenic… 
The dominant mutation Suppressor of black indicates that de novo pyrimidine biosynthesis is involved in the Drosophila tan pigmentation pathway
It is proposed that diminished end-product inhibition of de novo p Skyrimidine biosynthesis in Su(b) flies increases available pyrimidine and consequently the β-alanine pool.
The physiological effects of dumpy mutations on de‐novo pyrimidine synthesis in Drosophila melanogaster
Results accumulate to support the theory that dp might have some regulatory effect on the pyrimidine synthesis which might be caused by an alteration in the chitin synthesis.
Mutations affecting phenol oxidase activity inDrosophila: quicksilver andtyrosinase-1
The diphenol oxidase activity in double mutant combinations shows that these mutations and Dox-A2 (Pentzet al., 1986) affect this enzyme in different ways.


Beta-alanine and adaptation in Drosophila.
Beta-Alanine Utilization of Ebony and Non-ebony Drosophila melanogaster
Carbon-14-labeled β-alanine was injected into newly formed Drosophila melanogaster female pupae. Homozygous ebony deposited less C14in pupal sheaths, deposited more C14in adult body extracts and
β Alanine and cuticle maturation in Drosophila
Evidence is provided that β alanine also plays a role in the tanning of adult fruit-flies and is suggested to be a constitutent of the cuticles of many insects.
Tyrosine and catecholamine metabolism in wild-type Drosophila melanogaster and a mutant, ebony.
Beta-Alanine metabolism in the housefly, Musca domestica: studies on anabolism in the early puparium.
6-Azauracil induced phenocopies of rudimentary wing mutants and their suppression by a suppressor mutant of rudimentary in Drosophila melanogaster.
It is concluded that the induced wing defects are true phenocopies of rudimentary wings and provide additional evidence for a deficient pyrimidine biosynthesis in rudimentary mutants and encourage the use of antimetabolites in the biochemical investigation of morphological mutants of Drosophila.