Intergenic mRNA molecules resulting from trans-splicing.

  title={Intergenic mRNA molecules resulting from trans-splicing.},
  author={Csaba Finta and Peter G. Zaphiropoulos},
  journal={The Journal of biological chemistry},
  volume={277 8},
Accumulated recent evidence is indicating that alternative splicing represents a generalized process that increases the complexity of human gene expression. Here we show that mRNA production may not necessarily be limited to single genes, as human liver also has the potential to produce a variety of hybrid cytochrome P450 3A mRNA molecules. The four known cytochrome P450 3A genes in humans, CYP3A4, CYP3A5, CYP3A7, and CYP3A43, share a high degree of similarity, consist of 13 exons with… CONTINUE READING
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