• DOI:10.1038/s42003-021-02255-2
• Corpus ID: 235631160

Intergenerational trauma transmission is associated with brain metabotranscriptome remodeling and mitochondrial dysfunction

@article{Alhassen2021IntergenerationalTT,
  title={Intergenerational trauma transmission is associated with brain metabotranscriptome remodeling and mitochondrial dysfunction},
  author={Sammy Alhassen and Siwei Chen and Lamees Alhassen and Alvin Phan and Mohammad Khoudari and Angele De Silva and Huda Barhoosh and Zitong Wang and Chelsea Marie T. Parrocha and Emily C. Shapiro and Charity Henrich and Zicheng Wang and L{\'e}on Mutesa and Pierre Baldi and Geoffrey W. Abbott and Amal Alachkar},
  journal={Communications Biology},
  year={2021},
  volume={4}
}

• Sammy Alhassen, Siwei Chen, +13 authors A. Alachkar
• Published 24 June 2021
• Biology, Psychology
• Communications Biology

Intergenerational trauma increases lifetime susceptibility to depression and other psychiatric disorders. Whether intergenerational trauma transmission is a consequence of in-utero neurodevelopmental disruptions versus early-life mother–infant interaction is unknown. Here, we demonstrate that trauma exposure during pregnancy induces in mouse offspring social deficits and depressive-like behavior. Normal pups raised by traumatized mothers exhibited similar behavioral deficits to those induced in pups raised by their biological traumatized mothers. Good caregiving by normal mothers did not reverse prenatal trauma-induced behaviors, indicating a two-hit stress mechanism comprising both in-utero abnormalities and early-life poor parenting. The behavioral deficits were associated with profound changes in the brain metabotranscriptome. Striking increases in the mitochondrial hypoxia marker and epigenetic modifier 2-hydroxyglutaric acid in the brains of neonates and adults exposed prenatally to trauma indicated mitochondrial dysfunction and epigenetic mechanisms. Bioinformatic analyses revealed stress- and hypoxia-response metabolic pathways in the neonates, which produced long-lasting alterations in mitochondrial energy metabolism and epigenetic processes (DNA and chromatin modifications). Most strikingly, early pharmacological interventions with acetyl-L-carnitine (ALCAR) supplementation produced long-lasting protection against intergenerational trauma-induced depression. Sammy Alhassen, Siwei Chen, et al. use mouse models to examine the effects of prenatal and postnatal stress on metabolomic and transcriptomic pathways in the brain. Their results suggest that altered mitochondrial metabolism may underlie trauma-induced behavioral deficits, and that correcting metabolism with ALCAR supplementation may protect against intergenerational transmission of traumatic stress.