Intergenerational trauma transmission is associated with brain metabotranscriptome remodeling and mitochondrial dysfunction

  title={Intergenerational trauma transmission is associated with brain metabotranscriptome remodeling and mitochondrial dysfunction},
  author={Sammy Alhassen and Siwei Chen and Lamees Alhassen and Alvin Phan and Mohammad Khoudari and Angele De Silva and Huda Barhoosh and Zitong Wang and Chelsea Marie T. Parrocha and Emily C. Shapiro and Charity Henrich and Zicheng Wang and L{\'e}on Mutesa and Pierre Baldi and Geoffrey W. Abbott and Amal Alachkar},
  journal={Communications Biology},
Intergenerational trauma increases lifetime susceptibility to depression and other psychiatric disorders. Whether intergenerational trauma transmission is a consequence of in-utero neurodevelopmental disruptions versus early-life mother–infant interaction is unknown. Here, we demonstrate that trauma exposure during pregnancy induces in mouse offspring social deficits and depressive-like behavior. Normal pups raised by traumatized mothers exhibited similar behavioral deficits to those induced in… 
Epigenome-wide meta-analysis of PTSD symptom severity in three military cohorts implicates DNA methylation changes in genes involved in immune system and oxidative stress
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Precision Medicine: Neuropsychodynamic Psychiatry Model of Major Depressive Disorder
  • Huang Yaqi
  • Psychology
    Advances in Social Science, Education and Humanities Research
  • 2022
Major Depressive Disorder (MDD) is one of the most extensive types of psychiatric disorders. It refers to various symptoms and considerable rates of relapse, where episodes rarely resolve completely
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