Intergenerational transmission of insulin resistance and type 2 diabetes.

  title={Intergenerational transmission of insulin resistance and type 2 diabetes.},
  author={Lucilla Poston},
  journal={Progress in biophysics and molecular biology},
  volume={106 1},
Studies in women with type 1 or type 2 diabetes mellitus (DM) and their children suggest that the in utero 'diabetic' environment in which the fetus develops can increase the risk of diabetes in the child, in a non-genetic but heritable fashion. Studies in rodents provide strong evidence for maternal transmission of diabetes, but are based primarily on a model type 1 DM and there is no standard animal model of type 2 DM in pregnancy or of gestational diabetes mellitus (GDM), although those… CONTINUE READING