Interferons induce an antiviral state in human pancreatic islet cells.

  title={Interferons induce an antiviral state in human pancreatic islet cells.},
  author={Monica Hultcrantz and Michael H. H{\"u}hn and Monika Anna Wolf and Annika Ohrfelt Olsson and Stella Jacobson and Bryan Raymond George Williams and Olle Korsgren and Malin Flodstr{\"o}m-Tullberg},
  volume={367 1},
Enterovirus infections, in particular those with Coxsackieviruses, have been linked to the development of type 1 diabetes (T1D). Although animal models have demonstrated that interferons (IFNs) regulate virus-induced T1D by acting directly on the beta cell, little is known on the human pancreatic islet response to IFNs. Here we show that human islet cells respond to IFNs by expressing signature genes of antiviral defense. We also demonstrate that they express three intracellular sensors for… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 44 extracted citations

Recent acquisitions on the genetic basis of autoimmune disease.

Frontiers in bioscience : a journal and virtual library • 2008
View 20 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…