Interferons in the central nervous system: A few instruments play many tunes
@article{Owens2014InterferonsIT, title={Interferons in the central nervous system: A few instruments play many tunes}, author={Trevor Owens and Reza Khorooshi and Agnieszka Wlodarczyk and Nasrin Asgari}, journal={Glia}, year={2014}, volume={62} }
Interferons (IFNs) are implicated as an important component of the innate immune system influencing viral infections, inflammation, and immune surveillance. We review here the complex biological activity of IFNs in the central nervous system (CNS) and associated glial–immune interactions, with focus specifically on the Type I IFNs in physiological and pathological conditions. IFN‐α and IFN‐β are the predominant Type I IFNs in the CNS. They are produced in the CNS by glial cells, mostly…
86 Citations
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