Interferons and their use in persistent viral infections.

  title={Interferons and their use in persistent viral infections.},
  author={St{\'e}phane Chevaliez and Jean-Michel Pawlotsky},
  journal={Handbook of experimental pharmacology},
In 2007, the world celebrated the 50th anniversary of the discovery of interferon (IFN) by Isaacs and Lindenmann. Subsequently, the IFN-alpha gene was cloned, fully sequenced and IFN-alpha was produced in recombinant form. Recombinant IFN-alpha is now used as the basis for treatment of chronic hepatitis C virus infection and can also be used to treat certain forms of chronic hepatitis B virus infections. IFNs have also been used in other viral infections, although with less success. The… CONTINUE READING


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