Interferons and the Immunogenic Effects of Cancer Therapy.

  title={Interferons and the Immunogenic Effects of Cancer Therapy.},
  author={Andy J. Minn},
  journal={Trends in immunology},
  volume={36 11},
Much of our understanding on resistance mechanisms to conventional cancer therapies such as chemotherapy and radiation has focused on cell intrinsic properties that antagonize the detrimental effects of DNA and other cellular damage. However, it is becoming clear that the immune system and/or innate immune signaling pathways can integrate with these intrinsic mechanisms to profoundly influence treatment efficacy. In this context, recent evidence indicates that interferon (IFN) signaling has an… CONTINUE READING
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