Interferons and Ribavirin Effectively Inhibit Norwalk Virus Replication in Replicon-Bearing Cells

@article{Chang2007InterferonsAR,
  title={Interferons and Ribavirin Effectively Inhibit Norwalk Virus Replication in Replicon-Bearing Cells},
  author={Kyeong-Ok Chang and D. George},
  journal={Journal of Virology},
  year={2007},
  volume={81},
  pages={12111 - 12118}
}
ABSTRACT The development of effective therapies for noroviral gastroenteritis has been hampered by the absence of a cell culture system. Recently, we reported the generation of Norwalk virus (NV) replicon-bearing cells in BHK21 and Huh-7 cells and demonstrated that alpha interferon (IFN-α) effectively inhibited the replication of NV in these cells. In continuing studies for screening potential antinoroviral agents, we tested IFN-γ and ribavirin for their effects on NV replication in the cells… Expand
Antiviral activity of nucleoside analogues against norovirus.
Biodegradable nanogels for oral delivery of interferon for norovirus infection.
Replication of Human Norovirus RNA in Mammalian Cells Reveals Lack of Interferon Response
Type I and Type II Interferons Inhibit the Translation of Murine Norovirus Proteins
Inhibition of norovirus replication by the nucleoside analogue 2'-C-methylcytidine.
Inhibition of Calcineurin or IMP Dehydrogenase Exerts Moderate to Potent Antiviral Activity against Norovirus Replication
Inhibition of norovirus replication by morpholino oligomers targeting the 5′-end of the genome
Norovirus replication and attenuation
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 34 REFERENCES
Stable expression of a Norwalk virus RNA replicon in a human hepatoma cell line.
Inhibition of subgenomic hepatitis C virus RNA in Huh‐7 cells: ribavirin induces mutagenesis in HCV RNA
Synergistic inhibition of intracellular hepatitis C virus replication by combination of ribavirin and interferon- alpha.
The hepatitis C virus replicon system and its application to molecular studies.
Replication of Norovirus in Cell Culture Reveals a Tropism for Dendritic Cells and Macrophages
The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen
Antiviral Actions of Interferons
  • C. Samuel
  • Biology, Medicine
  • Clinical Microbiology Reviews
  • 2001
...
1
2
3
4
...