Interferons, signal transduction pathways, and the central nervous system.

  title={Interferons, signal transduction pathways, and the central nervous system.},
  author={Shreeram C. Nallar and Dhananjaya V. Kalvakolanu},
  journal={Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research},
  volume={34 8},
The interferon (IFN) family of cytokines participates in the development of innate and acquired immune defenses against various pathogens and pathogenic stimuli. Discovered originally as a proteinaceous substance secreted from virus-infected cells that afforded immunity to neighboring cells from virus infection, these cytokines are now implicated in various human pathologies, including control of tumor development, cell differentiation, and autoimmunity. It is now believed that the IFN system… CONTINUE READING