Interferon-tau modulates phorbol ester-induced production of prostaglandin and expression of cyclooxygenase-2 and phospholipase-A(2) from bovine endometrial cells.

@article{Binelli2000InterferontauMP,
  title={Interferon-tau modulates phorbol ester-induced production of prostaglandin and expression of cyclooxygenase-2 and phospholipase-A(2) from bovine endometrial cells.},
  author={Mario Binelli and Aydin Guzeloglu and Lokenga Badinga and Daniel Robert Arnold and J. Claude Sirois and Thomas R. Hansen and William Watters Thatcher},
  journal={Biology of reproduction},
  year={2000},
  volume={63 2},
  pages={417-24}
}
Antiluteolytic actions of bovine interferon-tau (bIFN-tau) require suppression of prostaglandin F(2 alpha) (PGF(2 alpha)) production. Our objective was to test whether bIFN-tau could block PGF(2 alpha) production and synthesis of phospholipase A(2) (PLA(2)) and cyclooxygenase-2 (COX-2) enzymes induced by a protein kinase C (PKC) stimulator (phorbol 12,13 dibutyrate; PDBu). Bovine endometrial epithelial (BEND) cells were treated with PDBu in the presence or absence of bIFN-tau. Medium samples… CONTINUE READING

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