Interferon-stimulated gene of 20 kDa protein (ISG20) degrades RNA of hepatitis B virus to impede the replication of HBV in vitro and in vivo

@inproceedings{Leong2016InterferonstimulatedGO,
  title={Interferon-stimulated gene of 20 kDa protein (ISG20) degrades RNA of hepatitis B virus to impede the replication of HBV in vitro and in vivo},
  author={Chean Ring Leong and Kenji Funami and Hiroyuki Oshiumi and Deng Mengao and Hiromi Takaki and Misako Matsumoto and Hussein H. Aly and Koichi Watashi and Kazuaki Chayama and Tsukasa Seya},
  booktitle={Oncotarget},
  year={2016}
}
Hepatitis B virus (HBV) barely induces host interferon (IFN)-stimulated genes (ISGs), which allows efficient HBV replication in the immortalized mouse hepatocytes as per human hepatocytes. Here we found that transfection of Isg20 plasmid robustly inhibits the HBV replication in HBV-infected hepatocytes irrespective of IRF3 or IFN promoter activation. Transfection of Isg20 is thus effective to eradicate HBV in the infected hepatocytes. Transfection of HBV genome or ε-stem of HBV pgRNA (active… CONTINUE READING
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