Interferon-stimulated Gene 15 (ISG15) is a trigger for tumorigenesis and metastasis of hepatocellular carcinoma

@inproceedings{Li2014InterferonstimulatedG1,
  title={Interferon-stimulated Gene 15 (ISG15) is a trigger for tumorigenesis and metastasis of hepatocellular carcinoma},
  author={Chong Li and Ji Wang and Hong Zhang and Mingao Zhu and Feifei Chen and Yufeng Hu and Hudan Liu and Hong Zhu},
  booktitle={Oncotarget},
  year={2014}
}
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide with poor prognosis. IFN-stimulated genes 15 (ISG15) is an ubiquitin-like molecule that is strongly upregulated by type I interferons as a primary response to diverse microbial and cellular stress stimuli. However, the role of ISG15 in HCC remains unclear. In this study, we investigated the function of ISG15 during HCC progression and related mechanism using clinicopathological data, cell line and xenograft model. Our… CONTINUE READING

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