Interferon-signaling pathway: associations with colon and rectal cancer risk and subsequent survival.

  title={Interferon-signaling pathway: associations with colon and rectal cancer risk and subsequent survival.},
  author={Martha L. Slattery and Abbie Lundgreen and Kristina L Bondurant and Roger K Wolff},
  volume={32 11},
Interferons (IFNs) are proteins involved in many functions including antiviral and antimicrobial response, apoptosis, cell cycle control and mediating other cytokines. IFN gamma (IFNG) is a proinflammatory cytokine that modulates many immune-related genes. In this study we examine genetic variation in IFNG, IFNGR1, IFNGR2 and interferon regulatory factors (IRFs) to determine associations with colon and rectal cancer and survival after diagnosis. We include data from two population-based… CONTINUE READING


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