Interferon signaling and treatment outcome in chronic hepatitis C.

@article{SarasinFilipowicz2008InterferonSA,
  title={Interferon signaling and treatment outcome in chronic hepatitis C.},
  author={Magdalena Sarasin-Filipowicz and Edward J. Oakeley and François H. T. Duong and Verena Christen and Luigi Maria Terracciano and W. Filipowicz and Markus H Heim},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 19},
  pages={
          7034-9
        }
}
Hepatitis C virus (HCV) infection is a major cause of chronic liver disease worldwide. The current standard therapy for chronic hepatitis C (CHC) consists of a combination of pegylated IFN alpha (pegIFNalpha) and ribavirin. It achieves a sustained viral clearance in only 50-60% of patients. To learn more about molecular mechanisms underlying treatment failure, we investigated IFN-induced signaling in paired liver biopsies collected from CHC patients before and after administration of… CONTINUE READING

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