Interferon response induced by Toll-like receptor signaling.

  title={Interferon response induced by Toll-like receptor signaling.},
  author={Osamu Takeuchi and Hiroaki Hemmi and Shizuo Akira},
  journal={Journal of endotoxin research},
  volume={10 4},
Toll-like receptors (TLRs) are essential for the recognition of distinct pathogen-associated molecular patterns (PAMPs). Activation of TLRs induces intracellular signaling pathways which lead to the production of pro-inflammatory cytokines, chemokines, and interferon (IFN)-inducible genes. TIR domain containing adaptor molecules in turn determine the signaling specificity of the response. Recent studies demonstrated that serine/threonine kinases IKK-i/TBK1 are critical for the regulation of IFN… CONTINUE READING


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