Interferon removes its own receptors as it blocks the division of Daudi cells.

@article{Eid1988InterferonRI,
  title={Interferon removes its own receptors as it blocks the division of Daudi cells.},
  author={Pierre Eid and M T Bandu and Gilles Uz{\'e} and Knud Erik Mogensen},
  journal={European journal of biochemistry},
  year={1988},
  volume={171 3},
  pages={
          675-82
        }
}
The Burkitt-derived line, Daudi, whose proliferation is inhibited by human alpha-interferon (IFN-alpha), was treated with 125I-labelled recombinant human IFN-alpha A. After separation from unbound ligand, cell-bound IFN was extracted with the detergent digitonin yielding soluble and insoluble complexes of IFN and receptor, together with a certain amount of uncomplexed IFN. 1. Soluble complexes were stable enough to be separated from uncomplexed IFN by permeation chromatography. Treatment of… CONTINUE READING
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