Interferon regulatory factor-7 modulates experimental autoimmune encephalomyelitis in mice

Abstract

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) with unknown etiology. Interferon-β (IFN-β), a member of the type I IFN family, is used as a therapeutic for MS and the IFN signaling pathway is implicated in MS susceptibility. Interferon regulatory factor 7 (IRF7) is critical for the induction and positive feedback… (More)
DOI: 10.1186/1742-2094-8-181

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