Interferon regulatory factor 7 is activated by a viral oncoprotein through RIP-dependent ubiquitination.

@article{Huye2007InterferonRF,
  title={Interferon regulatory factor 7 is activated by a viral oncoprotein through RIP-dependent ubiquitination.},
  author={Leslie Erskine Huye and Shunbin Ning and Michelle Kelliher and JosephS. Pagano},
  journal={Molecular and cellular biology},
  year={2007},
  volume={27 8},
  pages={
          2910-8
        }
}
As a key mediator of type I interferon (IFN) (IFN-alpha/beta) responses, IFN regulatory factor 7 (IRF7) is essential to host immune defenses. Activation of IRF7 generally requires virus-induced C-terminal phosphorylation, which leads to its nuclear accumulation and activation of target genes. Here we use the Epstein-Barr virus (EBV) oncoprotein LMP1, which activates IRF7, to identify factors involved in IRF7 activation. We demonstrate for the first time that RIP activates IRF7 and that RIP and… CONTINUE READING

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