Interferon regulatory factor 4 attenuates Notch signaling to suppress the development of chronic lymphocytic leukemia

@inproceedings{Shukla2016InterferonRF,
  title={Interferon regulatory factor 4 attenuates Notch signaling to suppress the development of chronic lymphocytic leukemia},
  author={Vipul Shukla and Ashima Shukla and Shantaram S. Joshi and Runqing Lu},
  booktitle={Oncotarget},
  year={2016}
}
Molecular pathogenesis of Chronic Lymphocytic Leukemia (CLL) is not fully elucidated. Genome wide association studies have linked Interferon Regulatory Factor 4 (IRF4) to the development of CLL. We recently established a causal relationship between low levels of IRF4 and development of CLL. However, the molecular mechanism through which IRF4 suppresses CLL development remains unclear. Deregulation of Notch signaling pathway has been identified as one of the most recurrent molecular anomalies in… CONTINUE READING