Interferon regulatory factor 3 is necessary for induction of antiviral genes during human cytomegalovirus infection.

@article{Defilippis2006InterferonRF,
  title={Interferon regulatory factor 3 is necessary for induction of antiviral genes during human cytomegalovirus infection.},
  author={Victor R Defilippis and Bridget Robinson and Thomas M Keck and Scott G Hansen and Jay A. Nelson and Klaus Fr{\"u}h},
  journal={Journal of virology},
  year={2006},
  volume={80 2},
  pages={1032-7}
}
Viral infection activates interferon regulatory factor 3 (IRF3), a cofactor for the induction of interferon-stimulated genes (ISGs). The role of IRF3 in the activation of ISGs by human cytomegalovirus (HCMV) is controversial despite the fact that HCMV has consistently been shown to induce ISGs during infection of fibroblasts. To address the function of IRF3 in HCMV-mediated ISG induction, we monitored ISG expression and global gene expression in HCMV-infected cells in which IRF3 function had… CONTINUE READING
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