Interferon regulatory factor 3 and type I interferons are protective in alcoholic liver injury in mice by way of crosstalk of parenchymal and myeloid cells.

@article{Petrasek2011InterferonRF,
  title={Interferon regulatory factor 3 and type I interferons are protective in alcoholic liver injury in mice by way of crosstalk of parenchymal and myeloid cells.},
  author={Jan Petrasek and Angela Dolganiuc and T{\'i}mea Cs{\'a}k and Bharath Nath and Istvan Hritz and Karen Kodys and Donna Catalano and Evelyn A Kurt-Jones and Pranoti Mandrekar and Gyongyi Szabo},
  journal={Hepatology},
  year={2011},
  volume={53 2},
  pages={649-60}
}
UNLABELLED Alcoholic liver disease (ALD) features increased hepatic exposure to bacterial lipopolysaccharide (LPS). Toll-like receptor-4 (TLR4) recognizes LPS and activates signaling pathways depending on MyD88 or TRIF adaptors. We previously showed that MyD88 is dispensable in ALD. TLR4 induces Type I interferons (IFNs) in an MyD88-independent manner that… CONTINUE READING