Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon–dependent exhaustion

@article{Sato2009InterferonRF,
  title={Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon–dependent exhaustion},
  author={Taku Sato and Nobuyuki Onai and Hiroki Yoshihara and Fumio Arai and Toshio Suda and Toshiaki Ohteki},
  journal={Nature Medicine},
  year={2009},
  volume={15},
  pages={696-700}
}
Type I interferons (IFNs), a family of cytokines, orchestrate numerous biological and cellular processes. Although it is well known that type I IFNs are essential for establishing the host antiviral state, their role in hematopoietic homeostasis has not been studied. Here we show that type I IFNs induce proliferation and exhaustion in hematopoietic stem cells (HSCs) and that interferon regulatory factor-2 (IRF2), a transcriptional suppressor of type I IFN signaling, preserves the self-renewal… CONTINUE READING
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