Interferon-regulatory-factor 1 controls Toll-like receptor 9-mediated IFN-beta production in myeloid dendritic cells.

@article{Schmitz2007Interferonregulatoryfactor1C,
  title={Interferon-regulatory-factor 1 controls Toll-like receptor 9-mediated IFN-beta production in myeloid dendritic cells.},
  author={Frank W Schmitz and Antje Heit and Simone Guggemoos and Anne B. Krug and Joerg Mages and Matthias Schiemann and Heiko Adler and Ingo Drexler and Tobias Haas and Roland Lang and Hermann Wagner},
  journal={European journal of immunology},
  year={2007},
  volume={37 2},
  pages={315-27}
}
Activation of interferon regulatory factor (IRF)-3 and/or IRF-7 drives the expression of antiviral genes and the production of alpha/beta IFN, a hallmark of antiviral responses triggered by Toll-like receptors (TLR). Here we describe a novel antiviral signaling pathway operating in myeloid (m) dendritic cells (DC) and macrophages that does not require IRF-3 and/or IRF-7 but is driven by IRF-1. IRF-1 together with myeloid differentiation factor 88 (MyD88) or IL-1 receptor-associated kinase (IRAK… CONTINUE READING
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