Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity

  title={Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity},
  author={Camie W Y Chan and Emily B. Crafton and Hong-Ni Fan and James Flook and Kiyoshi Yoshimura and Mario Skarica and Dirk G Brockstedt and Thomas W Dubensky and Monique F Stins and Lewis L. Lanier and Drew Mark Pardoll and Franck Housseau},
  journal={Nature Medicine},
Natural killer (NK) cells and dendritic cells (DCs) are, respectively, central components of innate and adaptive immune responses. We describe here a third DC lineage, termed interferon-producing killer DCs (IKDCs), distinct from conventional DCs and plasmacytoid DCs and with the molecular expression profile of both NK cells and DCs. They produce substantial amounts of type I interferons (IFN) and interleukin (IL)-12 or IFN-γ, depending on activation stimuli. Upon stimulation with CpG… CONTINUE READING
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Cross-Talk between activated human NK cells and CD4+ T cells via OX40–OX40 ligand interactions

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