Interferon-mediated enhancement of metastasis. Are MHC antigens involved?

  title={Interferon-mediated enhancement of metastasis. Are MHC antigens involved?},
  author={Pierluigi Lollini and Carla de Giovanni and Brunella Del Re and Giordano Nicoletti and Giorgio Prodi and Patrizia Nanni},
  journal={Clinical & Experimental Metastasis},
The relationship between major histocompatibility complex (MHC) antigens and metastasis was investigated on B16 melanoma variants. B16 cell lines express low amounts of murine MHC (H-2) antigens. A high expression can be induced in line B16-A by in vitro treatment with immune interferon (IFN-gamma) or by in vivo transplant in allogeneic mice. The increase… CONTINUE READING