Interferon-lambda polymorphisms and hepatitis C virus clearance revisited.

  title={Interferon-lambda polymorphisms and hepatitis C virus clearance revisited.},
  author={Joachim Lupberger and Daniel Jeffery Felmlee and Thomas F Baumert},
  volume={58 1},
reprinted with permission) Chronic infection with hepatitis C virus (HCV) is a common cause of liver cirrhosis and cancer. We performed RNA sequencing in primary human hepatocytes activated with synthetic double-stranded RNA to mimic HCV infection. Upstream of IFNL3 (IL28B) on chromosome 19q13.13, we discovered a new transiently induced region that harbors a dinucleotide variant ss469415590 (TT or ∆G), which is in high linkage disequilibrium with rs12979860, a genetic marker strongly associated… CONTINUE READING