Interferon induction of fibroblast proteins with guanylate binding activity.

@article{Cheng1983InterferonIO,
  title={Interferon induction of fibroblast proteins with guanylate binding activity.},
  author={Yuan Shan Cheng and R. J. Colonno and Fang Hao Yin},
  journal={The Journal of biological chemistry},
  year={1983},
  volume={258 12},
  pages={
          7746-50
        }
}
Treatment of human diploid fibroblastic cells with interferon induces the synthesis of two guanylate binding proteins (GBP) with molecular weights of 67,000 and 56,000. The Mr = 67,000 protein (67K GBP) is synthesized upon treatment with either alpha-, beta-, or gamma-interferon. Among these interferons, gamma-interferon induces a higher level of 67K GBP synthesis. The 67K GBP synthesized in either beta- or gamma-interferon-treated cells has two charge forms with isoelectric points of 6.0 and 5… CONTINUE READING

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