Interferon induction and function at the mucosal surface.

  title={Interferon induction and function at the mucosal surface.},
  author={Russell K. Durbin and Sergei V. Kotenko and Joan E Durbin},
  journal={Immunological reviews},
  volume={255 1},
Interferons (IFNs) are produced in response to virus infection and induce an antiviral state in virtually all cell types. In addition to upregulating the transcription of genes that inhibit virus replication, type I (or -α/β) IFNs also act to orchestrate the adaptive immune response to virus infection. Recently a new family of antiviral cytokines, the type III (or -λ) IFNs, has been identified that activate the same antiviral pathways via a distinct receptor. Although the identical… CONTINUE READING


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