Interferon-inducible expression of APOBEC3 editing enzymes in human hepatocytes and inhibition of hepatitis B virus replication.

@article{Bonvin2006InterferoninducibleEO,
  title={Interferon-inducible expression of APOBEC3 editing enzymes in human hepatocytes and inhibition of hepatitis B virus replication.},
  author={Marianne Bonvin and François Achermann and Isabell Greeve and Deborah Stroka and Adrian Keogh and Daniel Inderbitzin and Daniel Candinas and Peter Sommer and Simon Wain-Hobson and J P Vartanian and J. Greeve},
  journal={Hepatology},
  year={2006},
  volume={43 6},
  pages={1364-74}
}
Hypermutations in hepatitis B virus (HBV) DNA by APOBEC3 cytidine deaminases have been detected in vitro and in vivo, and APOBEC3G (A3G) and APOBEC3F (A3F) have been shown to inhibit the replication of HBV in vitro, but the presumably low or even absent hepatic expression of these enzymes has raised the question as to their physiological impact on HBV replication. We show that normal human liver expresses the mRNAs of APOBEC3B (A3B), APOBEC3C (A3C), A3F, and A3G. In primary human hepatocytes… CONTINUE READING
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