Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus

@article{Odhams2019InterferonIX,
  title={Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus},
  author={C. Odhams and A. Roberts and Susan K Vester and C. Duarte and Charlie T Beales and A. Clarke and S. Lindinger and Samuel J Daffern and Antonino Zito and Lingyan Chen and L. Jones and L. Boteva and D. Morris and K. Small and M. Fernando and D. C. Cunninghame Graham and T. Vyse},
  journal={Nature Communications},
  year={2019},
  volume={10}
}
Systemic lupus erythematosus (SLE) is an autoimmune disease, characterised by increased expression of type I interferon (IFN)-regulated genes and a striking sex imbalance towards females. Through combined genetic, in silico, in vitro, and ex vivo approaches, we define CXorf21, a gene of hitherto unknown function, which escapes X-chromosome inactivation, as a candidate underlying the Xp21.2 SLE association. We demonstrate that CXorf21 is an IFN-response gene and that the sexual dimorphism in… Expand
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