Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus

  title={Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus},
  author={Christopher A. Odhams and Amy L. Roberts and Susan K. Vester and Carolina S. T. Duarte and Charlie T Beales and Alexander J. Clarke and Sonja Lindinger and Samuel J Daffern and Antonino Zito and Lingyan Chen and Leonard L. Jones and Lora Boteva and David L. Morris and Kerrin S. Small and Michelle M. A. Fernando and Deborah S Cunninghame Graham and Timothy J. Vyse},
  journal={Nature Communications},
Systemic lupus erythematosus (SLE) is an autoimmune disease, characterised by increased expression of type I interferon (IFN)-regulated genes and a striking sex imbalance towards females. Through combined genetic, in silico, in vitro, and ex vivo approaches, we define CXorf21, a gene of hitherto unknown function, which escapes X-chromosome inactivation, as a candidate underlying the Xp21.2 SLE association. We demonstrate that CXorf21 is an IFN-response gene and that the sexual dimorphism in… 

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