Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element.

@article{Reich1987InterferoninducedTO,
  title={Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element.},
  author={Norbert O Reich and Bill Evans and Dawn Levy and Dale Fahey and Ellie Knight and J. E. Darnell},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1987},
  volume={84 18},
  pages={6394-8}
}
A human gene encoding an interferon-induced 15-kDa protein has been isolated from a genomic library. The gene appears to be single-copy and is composed of two exons, the first of which contains the ATG translation initiation codon. In vitro nuclear run-on assays showed that the transcription rate of the gene is stimulated after interferon treatment. To analyze transcriptional regulatory sequences, we constructed recombinant plasmids for use in transient transfection assays of HeLa cells… CONTINUE READING
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