Interferon-induced growth modulation: low dose maintenance of the antiproliferative response.

@article{Krueger1984InterferoninducedGM,
  title={Interferon-induced growth modulation: low dose maintenance of the antiproliferative response.},
  author={Leslie J. Krueger and R W Terry and Andrew J. Sussman and Anna C. Tate and David E Axelrod},
  journal={Journal of interferon research},
  year={1984},
  volume={4 1},
  pages={29-40}
}
Treatment of the Burkitt's lymphoma-derived Daudi cell line with human beta interferon (HuIFN-beta) results in a dose-dependent antiproliferative response. We have defined three phases including: (1) initiation, (2) maintenance, and (3) termination of the antiproliferative state. Each phase is characterized by specific growth modulatory properties. Initiation of the antiproliferative state with a single interferon dose requires 200 International Reference Units (IRU) per ml, depending on such… CONTINUE READING