Interferon-induced and double-stranded RNA-activated enzymes: a specific protein kinase and 2',5'-oligoadenylate synthetases.

@article{Hovanessian1991InterferoninducedAD,
  title={Interferon-induced and double-stranded RNA-activated enzymes: a specific protein kinase and 2',5'-oligoadenylate synthetases.},
  author={Ara G. Hovanessian},
  journal={Journal of interferon research},
  year={1991},
  volume={11 4},
  pages={199-205}
}
Treatment of cells with interferon (IFN) results in the induction of two double-stranded RNA (dsRNA)-activated enzymes: a specific protein kinase and 2'-5' linked oligoadenylate [pppA(2'p5'A)n referred to as 2-5A] synthetases. The protein kinase, when activated by dsRNA, becomes autophosphorylated and catalyzes and phosphorylation of the protein synthesis initiation factor, eIF2. The 2-5A synthetases, when activated by dsRNA, form 2-5A molecules capable of activating a latent endoribonuclease… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

Similar Papers

Loading similar papers…