Interferon in chronic myeloid leukemia


The therapeutic efficacy of interferon-alpha (IFN-α) in the treatment of chronic myeloid leukemia is currently being tested in a number of institutional, interinstitutional, and international trials. There is no doubt that responses are achieved in many patients, and in a small subset complete eradication of clonogenic cells may be possible. However, it has not yet been shown that overall survival of patients treated with IFN-α is better than that of those treated with conventional cytoreductive drugs. There are still controversial opinions on problems such as dosages and duration of treatment, combination with cytostatic agents, definition of responses, and relevance of cytogenic and molecular data. An international workshop discussed the data on interferon therapy and attempted to define the role of interferon today in the management of chronic myeloid leukemia.

DOI: 10.1007/BF01788134

Cite this paper

@article{Griesshammer1990InterferonIC, title={Interferon in chronic myeloid leukemia}, author={Martin Griesshammer and R{\"{u}diger Hehlmann and Andreas Hochhaus and Moshe Talpaz and Sante Tura and Pierre Stryckmans and Nadji Allan and Jerome Tanzer and Hans J. Kolb and Hermann Heimpel}, journal={Annals of Hematology}, year={1990}, volume={67}, pages={101-106} }