Interferon in chronic myeloid leukaemia: past and future.

  title={Interferon in chronic myeloid leukaemia: past and future.},
  author={François Guilhot and Lydia Roy and Pierre-Jean Saulnier and Jo{\"e}lle Guilhot},
  journal={Best practice & research. Clinical haematology},
  volume={22 3},
Imatinib has revolutionized the therapy of chronic myeloid leukaemia. However the complete eradication of leukaemic stem cells is still a matter of discussion. Interferon (IFN) has been used in the past with success. However the proportion of patients who achieved sustained complete cytogenetic response was small. Recently, in addition to its direct antineoplastic effect and immunomodulatory activity, IFN has been shown to stimulate the quiescent leukaemic stem cells. Thus there is now a… CONTINUE READING

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