Interferon-gamma sensitizes colonic epithelial cell lines to physiological and therapeutic inducers of colonocyte apoptosis.

@article{Oconnell2000InterferongammaSC,
  title={Interferon-gamma sensitizes colonic epithelial cell lines to physiological and therapeutic inducers of colonocyte apoptosis.},
  author={J O'connell and Michael R Bennett and Kenneth Nally and G C O'sullivan and John Kevin Collins and Fergus Shanahan},
  journal={Journal of cellular physiology},
  year={2000},
  volume={185 3},
  pages={331-8}
}
Homeostasis in the colonic epithelium is achieved by a continuous cycle of proliferation and apoptosis, in which imbalances are associated with disease. Inflammatory bowel disease (IBD) and colon cancer are associated with either excessive or insufficient apoptosis of colonic epithelial cells, respectively. By using two colonic epithelial cell lines, HT29 and SW620, we investigated how the epithelial cell's sensitivity to apoptosis was regulated by the proinflammatory cytokine interferon-gamma… CONTINUE READING