Interferon-gamma reduces melanosomal antigen expression and recognition of melanoma cells by cytotoxic T cells.

@article{Poole2002InterferongammaRM,
  title={Interferon-gamma reduces melanosomal antigen expression and recognition of melanoma cells by cytotoxic T cells.},
  author={I Caroline Le Poole and Adam I. Riker and M Eugenia Quevedo and Lawrence S Stennett and Ena Wang and Francesco M. Marincola and W. Martin Kast and June K Robinson and Brian J. Nickoloff},
  journal={The American journal of pathology},
  year={2002},
  volume={160 2},
  pages={521-8}
}
In malignant melanoma, tumor-infiltrating lymphocytes are frequently reactive with melanosomal antigens. Achieving complete remissions by peptide therapy is frequently hampered by metastases evading immune recognition. The tumor microenvironment seems to favor reduced expression of target antigens by melanoma cells. Among candidate factors, interferon-gamma (IFN-gamma) (10(2) to 10(3) U/ml) suppressed expression of antigens MART-1, TRP-1, and gp100 by M14 melanoma cells as shown by… CONTINUE READING
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