Interferon-gamma rapidly increases peptide transporter (TAP) subunit expression and peptide transport capacity in endothelial cells.

@article{Ma1997InterferongammaRI,
  title={Interferon-gamma rapidly increases peptide transporter (TAP) subunit expression and peptide transport capacity in endothelial cells.},
  author={Wenbin Ma and Paul J Lehner and Peter Cresswell and Jordan S Pober and David Read Johnson},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 26},
  pages={16585-90}
}
Human cytotoxic T lymphocytes (CTL) recognize specific complexes of HLA class I molecules and peptides, which assemble when nascent class I molecules bind peptides transported from the cytoplasm into the endoplasmic reticulum by the heterodimeric transporter associated with antigen processing (TAP). Increased class I molecule expression on the cell surface increases the efficiency of CTL lysis. The kinetics of interferon (IFN)-gamma induction of TAP, peptide transport capacity, and HLA class I… CONTINUE READING
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