Interferon-gamma production by specific lung lymphocyte phenotypes in silicosis in mice.

@article{Davis2000InterferongammaPB,
  title={Interferon-gamma production by specific lung lymphocyte phenotypes in silicosis in mice.},
  author={Gerald S. Davis and Linda M. Pfeiffer and David R Hemenway},
  journal={American journal of respiratory cell and molecular biology},
  year={2000},
  volume={22 4},
  pages={491-501}
}
We recently described overproduction of interferon (IFN)-gamma by lung lymphocytes in mice with silicosis (11% of cells in air-control versus 19% of cells from silica-exposed mice; Davis and colleagues, Am. J. Respir. Cell Mol. Biol. 1999;20:813-824). We hypothesized that the increased IFN-gamma production might be due to selective enrichment of one lymphocyte phenotype. To test this hypothesis, small mononuclear cells from lung digest preparations of mice exposed 4 mo previously to… CONTINUE READING

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