Interferon gamma plays a critical role in induced cell death of effector T cell: a possible third mechanism of self-tolerance

@article{Liu1990InterferonGP,
  title={Interferon gamma plays a critical role in induced cell death of effector T cell: a possible third mechanism of self-tolerance},
  author={Yilun Liu and Charles A. Janeway},
  journal={The Journal of Experimental Medicine},
  year={1990},
  volume={172},
  pages={1735 - 1739}
}
We have used anti-T cell monoclonal antibodies (mAbs) as mimic ligands to study the effects of T cell receptor (TCR) ligation of cloned T helper type 1 cells in the presence or absence of accessory cells. Our results demonstrate that ligation of the TCR in the absence of accessory cells rapidly induces cell death. Cell death can be prevented by addition of spleen adherent cells, leading to strong clonal expansion. Induced cell death is inhibited by cyclosporin A and by anti-interferon gamma… CONTINUE READING

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