Interferon-gamma modulates protein kinase C activity in murine peritoneal macrophages.

  title={Interferon-gamma modulates protein kinase C activity in murine peritoneal macrophages.},
  author={Thomas A Hamilton and David Lee Becton and Scott D. Somers and P W Gray and D. O. Adams},
  journal={The Journal of biological chemistry},
  volume={260 3},
The content of Ca2+-, phospholipid-dependent protein kinase activity (protein kinase C) in murine peritoneal macrophages treated with recombinant interferon-gamma (IFN-gamma) has been investigated. Protein kinase C activity was solubilized by nonionic detergent extraction of sonicated cells and separated by high performance liquid chromatography on a TSK 4000 SW gel filtration column. The enzyme eluted from the column in a molecular weight range of 60-80 X 10(3) and was identified by virtue of… CONTINUE READING


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