Interferon-gamma is required for lupus nephritis in mice treated with the hydrocarbon oil pristane.

@article{Richards2001InterferongammaIR,
  title={Interferon-gamma is required for lupus nephritis in mice treated with the hydrocarbon oil pristane.},
  author={Hanno B. Richards and Minoru Satoh and J. Charles Jennette and Byron P. Croker and Hideo Yoshida and Westley H. Reeves},
  journal={Kidney international},
  year={2001},
  volume={60 6},
  pages={2173-80}
}
BACKGROUND Although the precise mechanisms leading to lupus nephritis remain obscure, both TH1 and TH2 cytokines have been implicated. The present study examined the roles of interleukin (IL)-4 and interferon-gamma (IFN-gamma) in a novel inducible form of lupus that develops in non-autoimmune mice treated with the hydrocarbon oil pristane. METHODS BALB/c IL-4 or IFN-gamma deficient mice (IL-4 -/-, IFNgamma -/-) and wild type controls (+/+) received either pristane or phosphate-buffered saline… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

Similar Papers

Loading similar papers…