Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice.

@article{Balomenos1998InterferongammaIR,
  title={Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice.},
  author={Dimitrios Balomenos and Robert Rumold and Argyrios N. Theofilopoulos},
  journal={The Journal of clinical investigation},
  year={1998},
  volume={101 2},
  pages={364-71}
}
Congenic MRL-lpr mice homozygous and heterozygous for the IFN-gamma gene disruption were created to assess the role of this pleotropic cytokine on the lymphoaccumulation and lupus-like disease of Fas-defective mice. Early death was prevented, and glomerulonephritis severely reduced in IFN-gamma-/- mice. Hypergammaglobulinemia was maintained with a switch from IgG2a to IgG1 predominance, but the dramatic decrease in levels of the dominant IgG2a anti-dsDNA autoantibodies was not associated with a… CONTINUE READING

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