Interferon-gamma is required for innate immunity to Cryptosporidium parvum in mice.

@article{Hayward2000InterferongammaIR,
  title={Interferon-gamma is required for innate immunity to Cryptosporidium parvum in mice.},
  author={Anthony R. Hayward and Kathryn Chmura and Mary Cosyns},
  journal={The Journal of infectious diseases},
  year={2000},
  volume={182 3},
  pages={1001-4}
}
Although CD4 T cells are required for recovery from cryptosporidial infection, mice with severe combined immunodeficiency (SCID) remain infected for long periods without ill effect. In contrast, mice whose ability to use interferon(IFN)-gamma is impaired, by neutralization or gene knockout, experience heavy cryptosporidial infection that may lead to death. To determine whether the innate immunity of SCID mice to Cryptosporidium parvum (CP) requires IFN-gamma, doubly immunodeficient C57BL/6 SCID… CONTINUE READING
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